Ontology highlight
ABSTRACT:
SUBMITTER: Alanine DGW
PROVIDER: S-EPMC6602525 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cell 20190613 1
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However, little is known about how human antibodies confer functional immunity against this antigen. We isolated a panel of human monoclonal antibodies (mAbs) against PfRH5 from peripheral blood B cells from vaccinees in the first clinical trial of a PfRH5-based vaccine. We identified a subset of mAbs with neutralizing act ...[more]