Ontology highlight
ABSTRACT:
SUBMITTER: Merlini M
PROVIDER: S-EPMC6602536 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Merlini Mario M Rafalski Victoria A VA Rios Coronado Pamela E PE Gill T Michael TM Ellisman Maya M Muthukumar Gayathri G Subramanian Keshav S KS Ryu Jae Kyu JK Syme Catriona A CA Davalos Dimitrios D Seeley William W WW Mucke Lennart L Nelson Robert B RB Akassoglou Katerina K
Neuron 20190205 6
Cerebrovascular alterations are a key feature of Alzheimer's disease (AD) pathogenesis. However, whether vascular damage contributes to synaptic dysfunction and how it synergizes with amyloid pathology to cause neuroinflammation and cognitive decline remain poorly understood. Here, we show that the blood protein fibrinogen induces spine elimination and promotes cognitive deficits mediated by CD11b-CD18 microglia activation. 3D molecular labeling in cleared mouse and human AD brains combined with ...[more]