Ontology highlight
ABSTRACT:
SUBMITTER: Han Q
PROVIDER: S-EPMC6602974 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190701 1
The HIV-1 envelope (Env) is the target for neutralizing antibodies and exists on the surface of virions in open or closed conformations. Difficult-to-neutralize viruses (tier 2) express Env in a closed conformation antigenic for broadly neutralizing antibodies (bnAbs) but not for third variable region (V3) antibodies. Here we show that select V3 macaque antibodies elicited by Env vaccination can neutralize 26% of otherwise tier 2 HIV-1 isolates in standardized virus panels. The V3 antibodies onl ...[more]