Ontology highlight
ABSTRACT:
SUBMITTER: Crotti A
PROVIDER: S-EPMC6603165 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Crotti Andrea A Sait Hameetha Rajamohamend HR McAvoy Kathleen M KM Estrada Karol K Ergun Ayla A Szak Suzanne S Marsh Galina G Jandreski Luke L Peterson Michael M Reynolds Taylor L TL Dalkilic-Liddle Isin I Cameron Andrew A Cahir-McFarland Ellen E Ransohoff Richard M RM
Scientific reports 20190701 1
Despite Bridging INtegrator 1 (BIN1) being the second most statistically-significant locus associated to Late Onset Alzheimer's Disease, its role in disease pathogenesis remains to be clarified. As reports suggest a link between BIN1, Tau and extracellular vesicles, we investigated whether BIN1 could affect Tau spreading via exosomes secretion. We observed that BIN1-associated Tau-containing extracellular vesicles purified from cerebrospinal fluid of AD-affected individuals are seeding-competent ...[more]