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GPCRomics: An Approach to Discover GPCR Drug Targets.

ABSTRACT: G protein-coupled receptors (GPCRs) are targets for ?35% of approved drugs but only ?15% of the ?800 human GPCRs are currently such targets. GPCRomics, the use of unbiased, hypothesis-generating methods [e.g., RNA-sequencing (RNA-seq)], with tissues and cell types to identify and quantify GPCR expression, has led to the discovery of previously unrecognized GPCRs that contribute to functional responses and pathophysiology and that may be therapeutic targets. The combination of GPCR expression data with validation studies (e.g., signaling and functional activities) provides opportunities for the discovery of disease-relevant GPCR targets and therapeutics. Here, we review insights from GPCRomic approaches, gaps in knowledge, and future directions by which GPCRomics can advance GPCR biology and the discovery of new GPCR-targeted drugs.

SUBMITTER: Insel PA

PROVIDER: S-EPMC6604616 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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GPCRomics: An Approach to Discover GPCR Drug Targets.

Insel Paul A PA Sriram Krishna K Gorr Matthew W MW Wiley Shu Z SZ Michkov Alexander A Salmerón Cristina C Chinn Amy M AM

Trends in pharmacological sciences 20190508 6

G protein-coupled receptors (GPCRs) are targets for ∼35% of approved drugs but only ∼15% of the ∼800 human GPCRs are currently such targets. GPCRomics, the use of unbiased, hypothesis-generating methods [e.g., RNA-sequencing (RNA-seq)], with tissues and cell types to identify and quantify GPCR expression, has led to the discovery of previously unrecognized GPCRs that contribute to functional responses and pathophysiology and that may be therapeutic targets. The combination of GPCR expression dat ...[more]

PMID: 31078319

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