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Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction.

ABSTRACT: Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner-Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity.

SUBMITTER: Murlykina MV

PROVIDER: S-EPMC6604699 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction.

Murlykina Maryna V MV Kolomiets Oleksandr V OV Kornet Maryna M MM Sakhno Yana I YI Desenko Sergey M SM Dyakonenko Victoriya V VV Shishkina Svetlana V SV Brazhko Oleksandr A OA Musatov Vladimir I VI Tsygankov Alexander V AV Van der Eycken Erik V EV Chebanov Valentyn A VA

Beilstein journal of organic chemistry 20190612

Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner-Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily ...[more]

PMID: 31293676

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