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Anomeric sugar boronic acid analogues as potential agents for boron neutron capture therapy.

ABSTRACT: After the development of accelerators as neutron source, the access to new suitable agents for boron neutron capture therapy (BNCT) became a major need. Among many others, sugar boronic acids have recently attracted attention as boron carriers. Herein we report the synthesis and preliminary biological studies of two new sugar analogues containing a boronic acid at the anomeric position. The analogues were obtained by hydroboration of proper open-chain terminal alkenes that, after quenching with water, spontaneously afforded cyclic boronic acids with hemiacetal-like structures.

SUBMITTER: Imperio D

PROVIDER: S-EPMC6604725 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Anomeric sugar boronic acid analogues as potential agents for boron neutron capture therapy.

Imperio Daniela D Del Grosso Erika E Fallarini Silvia S Lombardi Grazia G Panza Luigi L

Beilstein journal of organic chemistry 20190619

After the development of accelerators as neutron source, the access to new suitable agents for boron neutron capture therapy (BNCT) became a major need. Among many others, sugar boronic acids have recently attracted attention as boron carriers. Herein we report the synthesis and preliminary biological studies of two new sugar analogues containing a boronic acid at the anomeric position. The analogues were obtained by hydroboration of proper open-chain terminal alkenes that, after quenching with ...[more]

PMID: 31293685

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