TP53I11 suppresses epithelial-mesenchymal transition and metastasis of breast cancer cells.
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ABSTRACT:
SUBMITTER: Xiao T
PROVIDER: S-EPMC6605526 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
TP53I11 suppresses epithelial-mesenchymal transition and metastasis of breast cancer cells.
Xiao Tongqian T Xu Zhongjuan Z Zhang Hai H Geng Junsa J Qiao Yong Y Liang Yu Y Yu Yanzhen Y Dong Qun Q Suo Guangli G
BMB reports 20190601 6
Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatment upregulated the expression of HIF1α, but reduced TP53I11 protein levels and TP53I11 overexpression reduced HIF1α expression under normal culture and hypoxicconditions, and in xen ...[more]
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