Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XF
PROVIDER: S-EPMC6605792 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zhang Xiao-Feng XF Ajeti Visar V Tsai Nicole N Fereydooni Arash A Burns William W Murrell Michael M De La Cruz Enrique M EM Forscher Paul P
The Journal of cell biology 20190523 7
Serotonin (5-HT) is known to increase the rate of growth cone advance via cofilin-dependent increases in retrograde actin network flow and nonmuscle myosin II activity. We report that myosin II activity is regulated by PKC during 5-HT responses and that PKC activity is necessary for increases in traction force normally associated with these growth responses. 5-HT simultaneously induces cofilin-dependent decreases in actin network density and PKC-dependent increases in point contact density. Thes ...[more]