Ontology highlight
ABSTRACT:
SUBMITTER: Osorio L
PROVIDER: S-EPMC6605798 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
The Journal of cell biology 20190606 7
Isthmin1 (ISM1) was originally identified as a fibroblast group factor expressed in <i>Xenopus laevis</i> embryonic brain, but its biological functions remain unclear. The spatiotemporal distribution of ISM1, with high expression in the anterior primitive streak of the chick embryo and the anterior mesendoderm of the mouse embryo, suggested that ISM1 may regulate signaling by the NODAL subfamily of TGB-β cytokines that control embryo patterning. We report that ISM1 is an inhibitor of NODAL signa ...[more]