Ontology highlight
ABSTRACT:
SUBMITTER: David AF
PROVIDER: S-EPMC6605806 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
David Ana F AF Roudot Philippe P Legant Wesley R WR Betzig Eric E Danuser Gaudenz G Gerlich Daniel W DW
The Journal of cell biology 20190521 7
Dividing cells reorganize their microtubule cytoskeleton into a bipolar spindle, which moves one set of sister chromatids to each nascent daughter cell. Early spindle assembly models postulated that spindle pole-derived microtubules search the cytoplasmic space until they randomly encounter a kinetochore to form a stable attachment. More recent work uncovered several additional, centrosome-independent microtubule generation pathways, but the contributions of each pathway to spindle assembly have ...[more]