Ontology highlight
ABSTRACT:
SUBMITTER: Wong CK
PROVIDER: S-EPMC6605987 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Cancer biology & therapy 20190328 8
Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer with poor prognosis due to lack of druggable targets such as hormone and growth factor receptors. Therefore, identification of targetable regulators such as miRNAs could provide new avenues for therapeutic applications. Here, we report that the expression of miR-4417 is suppressed during the progression of TNBC cells from non-malignant to the malignant stage. MiR-4417 is localized to chromosome 1p36, a region with ...[more]