Ontology highlight
ABSTRACT:
SUBMITTER: Guan C
PROVIDER: S-EPMC6606003 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Guan Chen C Zhang Lingling L Wang Sixuan S Long Luye L Zhou Huaibin H Qian Shihan S Ma Mengni M Bai Fumao F Meng Qing H QH Lyu Jianxin J
Cancer biology & therapy 20190419 8
Prostate cancer (PCa) is the second frequently newly diagnosed cancer in men. Androgen deprivation therapy has been widely used to inhibit PCa growth but eventually fails in many patients. Androgen receptor and its downstream molecules like microRNAs could be promising therapeutic targets. We aimed to investigate the involvement of miR-21 in PCa tumorigenesis. We found that miR-21 was an unfavorable factor and correlated positively with tumor grade in PCa patients from TCGA database. MiR-21 was ...[more]