Ontology highlight
ABSTRACT:
SUBMITTER: Won E
PROVIDER: S-EPMC6606369 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Won Elizabeth E Basunia Azfar A Chatila Walid K WK Hechtman Jaclyn F JF Chou Joanne F JF Ku Geoffrey Y GY Chalasani Sree B SB Boyar Michelle S MS Goldberg Zoe Z Desai Avni M AM Tuvy Yaelle Y Berger Michael F MF Tang Laura L Kelsen David P DP Schattner Mark M Ilson David H DH Capanu Marinela M Solit David B DB Schultz Nikolaus N Janjigian Yelena Y YY
Clinical cancer research : an official journal of the American Association for Cancer Research 20190405 13
<h4>Purpose</h4>VEGFR2-directed therapy is commonly used to treat metastatic esophagogastric cancer, but disease progresses in most patients within months. Therapeutic resistance is likely mediated in part by co-occurring amplifications of the genes for multiple oncogenic receptor tyrosine kinases (RTK). We therefore tested the efficacy of combined inhibition of VEGFR1-3, PDGFα/β, and FGFR1-3 using nintedanib.<h4>Patients and methods</h4>Patients with metastatic esophagogastric adenocarcinoma an ...[more]