Ontology highlight
ABSTRACT:
SUBMITTER: Guerra-Rebollo M
PROVIDER: S-EPMC6606606 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Guerra-Rebollo Marta M Garrido Cristina C Sánchez-Cid Lourdes L Soler-Botija Carolina C Meca-Cortés Oscar O Rubio Nuria N Blanco Jerónimo J
Scientific reports 20190702 1
The existence of radio- and chemotherapy-surviving cancer stem cells is currently believed to explain the inefficacy of anti-glioblastoma (GBM) therapies. The aim of this study was to determine if a therapeutic strategy specifically targeting GBM stem cells (GSC) would completely eradicate a GBM tumor. In both the in vitro and the in vivo models, ganciclovir therapy targeting proliferating GSC promotes the survival of a quiescent, stem-like cell pool capable of reproducing the tumor upon release ...[more]