Ontology highlight
ABSTRACT:
SUBMITTER: Hirakata S
PROVIDER: S-EPMC6607011 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Hirakata Shigeki S Ishizu Hirotsugu H Fujita Aoi A Tomoe Yumiko Y Siomi Mikiko C MC
EMBO reports 20190430 7
Female sterile (1) Yb (Yb) is a primary component of Yb bodies, perinuclear foci considered to be the site of PIWI-interacting RNA (piRNA) biogenesis in Drosophila ovarian somatic cells (OSCs). Yb consists of three domains: Helicase C-terminal (Hel-C), RNA helicase, and extended Tudor (eTud) domains. We previously showed that the RNA helicase domain is necessary for Yb-RNA interaction, Yb body formation, and piRNA biogenesis. Here, we investigate the functions of Hel-C and eTud and reveal that H ...[more]