Ontology highlight
ABSTRACT:
SUBMITTER: Moreau D
PROVIDER: S-EPMC6607015 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Moreau Dimitri D Vacca Fabrizio F Vossio Stefania S Scott Cameron C Colaco Alexandria A Paz Montoya Jonathan J Ferguson Charles C Damme Markus M Moniatte Marc M Parton Robert G RG Platt Frances M FM Gruenberg Jean J
EMBO reports 20190522 7
Most cells acquire cholesterol by endocytosis of circulating low-density lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work suggested that the unconventional phospholipid lysobisphosphatidic acid (LBPA) may play a role in modulating the cholesterol flux through endosomes. In this study, we used the Prestwick library of FDA-approved compounds in a high-content, image-ba ...[more]