Unknown

Dataset Information

0

Analysis of common targets for circular RNAs.


ABSTRACT: BACKGROUND:The studies of functions of circular RNAs (circRNAs) are heavily focused on the regulation of gene expression through interactions with multiple miRNAs. However, the number of predicted target genes is typically overwhelming due to the synergistic complexity caused by two factors ? the binding of multiple miRNAs to a circRNA and the existence of multiple targets for each miRNA. Analysis of common targets (ACT) was designed to facilitate the identification of potential circRNA targets. RESULTS:We demonstrated the feasibility of the proposed feature/measurement to assess which genes are more likely to be regulated by circRNAs with given sequences by calculating the level of co-regulation by multiple miRNAs. The web service is made freely available at http://lab-x-omics.nchu.edu.tw/ACT_Server . CONCLUSIONS:ACT allows users to identify potential circRNA-regulated genes and their associated pathways for further investigation.

SUBMITTER: Lin YC 

PROVIDER: S-EPMC6607602 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Analysis of common targets for circular RNAs.

Lin Ya-Chi YC   Lee Yueh-Chun YC   Chang Kai-Li KL   Hsiao Kuei-Yang KY  

BMC bioinformatics 20190702 1


<h4>Background</h4>The studies of functions of circular RNAs (circRNAs) are heavily focused on the regulation of gene expression through interactions with multiple miRNAs. However, the number of predicted target genes is typically overwhelming due to the synergistic complexity caused by two factors ─ the binding of multiple miRNAs to a circRNA and the existence of multiple targets for each miRNA. Analysis of common targets (ACT) was designed to facilitate the identification of potential circRNA  ...[more]

Similar Datasets

| S-EPMC6189416 | biostudies-literature
| S-EPMC5667461 | biostudies-literature
| S-EPMC7838774 | biostudies-literature
| S-EPMC7648966 | biostudies-literature
2023-11-30 | E-MTAB-11171 | biostudies-arrayexpress
| S-EPMC6401440 | biostudies-literature
| S-EPMC6140489 | biostudies-literature
| S-EPMC8483823 | biostudies-literature
| S-EPMC5983963 | biostudies-literature
| S-EPMC5215283 | biostudies-literature