Ontology highlight
ABSTRACT:
SUBMITTER: Tobin RP
PROVIDER: S-EPMC6608076 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Tobin Richard P RP Davis Dana D Jordan Kimberly R KR McCarter Martin D MD
Journal of leukocyte biology 20170208 2
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that represent a formidable obstacle to the successful treatment of cancer. Patients with high frequencies of MDSCs have significantly decreased progression-free survival (PFS) and overall survival (OS). Whereas there is experimental evidence that the reduction of the number and/or suppressive function of MDSCs in mice improves the efficacy of anti-cancer therapies, there is notably less evidence fo ...[more]