Ontology highlight
ABSTRACT:
SUBMITTER: Lim PJ
PROVIDER: S-EPMC6609153 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Lim Pei Jin PJ Duarte Tiago L TL Arezes João J Garcia-Santos Daniel D Hamdi Amel A Pasricha Sant-Rayn SR Armitage Andrew E AE Mehta Hema H Wideman Sarah S Santos Ana G AG Santos-Gonçalves Andreia A Morovat Alireza A Hughes Jim R JR Soilleux Elizabeth E Wang Chia-Yu CY Bayer Abraham L AL Klenerman Paul P Willberg Christian B CB Hartley Richard C RC Murphy Michael P MP Babitt Jodie L JL Ponka Prem P Porto Graça G Drakesmith Hal H
Nature metabolism 20190513 5
Iron is critical for life but toxic in excess because of iron-catalysed formation of pro-oxidants that cause tissue damage in a range of disorders. The Nrf2 transcription factor orchestrates cell-intrinsic protective antioxidant responses, and the peptide hormone hepcidin maintains systemic iron homeostasis, but is pathophysiologically decreased in haemochromatosis and beta-thalassaemia. Here, we show that Nrf2 is activated by iron-induced, mitochondria-derived pro-oxidants and drives Bmp6 expre ...[more]