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Pancreatic stenting to prevent post-ERCP pancreatitis: a randomized multicenter trial.


ABSTRACT: Background and study aims  Acute pancreatitis (AP) is one of the most common gastrointestinal disorders leading to hospitalization and the most frequent complication of endoscopic retrograde cholangiopancreatography (ERCP). Besides pharmaco-prophylaxis, pancreatic stenting has been demonstrated to protect from post-ERCP pancreatitis (PEP). However, it remains unclear which patients benefit from pancreatic stenting. We therefore hypothesized that in an unselected population, inadvertent cannulation of the pancreatic duct during first-time ERCP increases risk of PEP and that this risk can be significantly reduced by pancreatic stenting. Patients and methods  This study was a multicenter, prospective, randomized controlled trial conducted at four European centers. A total of 167 patients undergoing first-time ERCP were enrolled in this trial. In the case of inadvertent cannulation of the pancreatic duct, patients were randomly assigned to receive either a 5 French plastic pancreatic stent of various length or no routine prophylactic intervention for PEP. Results  A total of 167 patients were included in the final analysis. Prophylactic stent insertion significantly reduced the rate of PEP during first-time ERCP (odds ratio 0.43; 95% confidence interval 0.19 - 0.98; P  = 0.04). The number needed to treat to prevent one case of PEP by prophylactic stent insertion after inadvertent cannulation of the pancreatic duct was 8.1 for the intention-to-treat population. Conclusion  In an unselected patient population, inadvertent cannulation of the pancreatic duct during first-time ERCP is associated with a high risk for PEP. This risk can be significantly reduced by prophylactic pancreatic stenting, which is a safe and feasible procedure.

SUBMITTER: Phillip V 

PROVIDER: S-EPMC6609234 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Pancreatic stenting to prevent post-ERCP pancreatitis: a randomized multicenter trial.

Phillip Veit V   Pukitis Aldis A   Epstein Alexey A   Hapfelmeier Alexander A   Haf David D   Schwab Miriam M   Demir Ihsan Ekin IE   Rosendahl Jonas J   Hoffmeister Albrecht A   Schmid Roland M RM   Weber Andreas A   Algül Hana H  

Endoscopy international open 20190703 7


<b>Background and study aims</b>  Acute pancreatitis (AP) is one of the most common gastrointestinal disorders leading to hospitalization and the most frequent complication of endoscopic retrograde cholangiopancreatography (ERCP). Besides pharmaco-prophylaxis, pancreatic stenting has been demonstrated to protect from post-ERCP pancreatitis (PEP). However, it remains unclear which patients benefit from pancreatic stenting. We therefore hypothesized that in an unselected population, inadvertent ca  ...[more]

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