Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically.

ABSTRACT: Complex karyotype (CK) with???3 abnormalities is detected in 10-12% of patients with acute myeloid leukemia (AML) and associated with poor prognosis. The most common unbalanced abnormalities found in CK result in loss of material from the 5q, 7q, and/or 17p chromosome arms. The presence of 5q, 7q, and/or 17p abnormalities denotes typical CK and their absence denotes atypical CK. Since molecular features of CK-AML are not well characterized, we investigated mutational status of 81 leukemia/cancer-associated genes in 160 clinically well-characterized patients. They included 136 patients with???3 exclusively unbalanced chromosome abnormalities, 96 of whom had a typical CK and 40 atypical CK, and 24 patients with???1 balanced abnormality in addition to???2 unbalanced ones. Patients with atypical CK-AML differed from those with typical CK-AML: they carried TP53 mutations less often (P?

SUBMITTER: Mrozek K 

PROVIDER: S-EPMC6609457 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature