Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence.

ABSTRACT: Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with cognitive impairment, which is considered a major determinant of functional outcome. Despite this, the etiology of the cognitive impairment is poorly understood, and no satisfactory cognitive treatments exist. Increasing evidence indicates that genetic risk for SCZ may contribute to cognitive impairment, whereas the genetic relationship between BD and cognitive function remains unclear. Here, we combined large genome-wide association study data on SCZ (n?=?82,315), BD (n?=?51,710), and general intelligence (n?=?269,867) to investigate overlap in common genetic variants using conditional false discovery rate (condFDR) analysis. We observed substantial genetic enrichment in both SCZ and BD conditional on associations with intelligence indicating polygenic overlap. Using condFDR analysis, we leveraged this enrichment to increase statistical power and identified 75 distinct genomic loci associated with both SCZ and intelligence, and 12 loci associated with both BD and intelligence at conjunctional FDR?

SUBMITTER: Smeland OB 

PROVIDER: S-EPMC6609490 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature