Ontology highlight
ABSTRACT:
SUBMITTER: Mollo N
PROVIDER: S-EPMC6609571 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Mollo Nunzia N Nitti Maria M Zerillo Lucrezia L Faicchia Deriggio D Micillo Teresa T Accarino Rossella R Secondo Agnese A Petrozziello Tiziana T Calì Gaetano G Cicatiello Rita R Bonfiglio Ferdinando F Sarnataro Viviana V Genesio Rita R Izzo Antonella A Pinton Paolo P Matarese Giuseppe G Paladino Simona S Conti Anna A Nitsch Lucio L
Frontiers in genetics 20190628
Mitochondrial dysfunction plays a primary role in neurodevelopmental anomalies and neurodegeneration of Down syndrome (DS) subjects. For this reason, targeting mitochondrial key genes, such as <i>PGC-1α/PPARGC1A</i>, is emerging as a good therapeutic approach to attenuate cognitive disability in DS. After demonstrating the efficacy of the biguanide metformin (a <i>PGC-1α</i> activator) in a cell model of DS, we extended the study to other molecules that regulate the <i>PGC-1α</i> pathway acting ...[more]