Ontology highlight
ABSTRACT:
SUBMITTER: Wang N
PROVIDER: S-EPMC6609695 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Cell death discovery 20190704
Pulmonary edema is a fatal complication of EV71-associated hand, foot, and mouth disease (HFMD). The pathogenesis of EV71-induced pulmonary edema remains largely unclear. In this study, we aimed to explore the roles of the capsid protein VP1 in the occurrence of EV71-induced pulmonary edema. The intranasal inoculation of recombinant VP1 protein caused lung inflammation with an elevation of inflammatory cytokines and neutrophils infiltration. Moreover, neutrophil extracellular traps (NETs) were o ...[more]