Mechanical shear controls bacterial penetration in mucus.
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ABSTRACT:
SUBMITTER: Figueroa-Morales N
PROVIDER: S-EPMC6609767 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Mechanical shear controls bacterial penetration in mucus.
Figueroa-Morales Nuris N Dominguez-Rubio Leonardo L Ott Troy L TL Aranson Igor S IS
Scientific reports 20190704 1
Mucus plays crucial roles in higher organisms, from aiding fertilization to protecting the female reproductive tract. Here, we investigate how anisotropic organization of mucus affects bacterial motility. We demonstrate by cryo electron micrographs and elongated tracer particles imaging, that mucus anisotropy and heterogeneity depend on how mechanical stress is applied. In shallow mucus films, we observe bacteria reversing their swimming direction without U-turns. During the forward motion, bact ...[more]
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