Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.
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ABSTRACT:
SUBMITTER: Olver TD
PROVIDER: S-EPMC6610000 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.
Olver T Dylan TD Edwards Jenna C JC Jurrissen Thomas J TJ Veteto Adam B AB Jones John L JL Gao Chen C Rau Christoph C Warren Chad M CM Klutho Paula J PJ Alex Linda L Ferreira-Nichols Stephanie C SC Ivey Jan R JR Thorne Pamela K PK McDonald Kerry S KS Krenz Maike M Baines Christopher P CP Solaro R John RJ Wang Yibin Y Ford David A DA Domeier Timothy L TL Padilla Jaume J Rector R Scott RS Emter Craig A CA
JACC. Basic to translational science 20190624 3
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet-fed, aortic-banded Ossabaw swine display an integrated physiological, morphological, and genetic phenotype evocative of cardio-metabolic heart failure. This new preclinical animal model displays a distinctive constellation of findings that are conceivably useful to ...[more]
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