Ontology highlight
ABSTRACT:
SUBMITTER: Olver TD
PROVIDER: S-EPMC6610000 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
JACC. Basic to translational science 20190624 3
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet-fed, aortic-banded Ossabaw swine display an integrated physiological, morphological, and genetic phenotype evocative of cardio-metabolic heart failure. This new preclinical animal model displays a distinctive constellation of findings that are conceivably useful to ...[more]