Targeting β2 subunit of Na⁺/K⁺-ATPase induces glioblastoma cell apoptosis through elevation of intracellular Ca².

ABSTRACT: Glioblastoma (GBM) is the most frequent brain cancer with poor prognosis and few therapies and urgently requires effective treatments. Na⁺/K⁺-ATPase is considered as a target for GBM therapy and development of anticancer drugs. Cardiac glycosides bind the Na⁺/K⁺-ATPase α subunit to inhibit enzymatic activity and are promising candidates for anticancer drug development including GBM. However, the comparatively higher doses required for effective anticancer actions cause severe cardiotoxicity. Selectively targeting the ATPase Na⁺/K⁺ transporting subunit beta 2 (ATP1B2) that is not expressed in the heart might avoid the cardiotoxicity. However, the effect of targeting ATP1B2 in GBM remains unknown. In this study, we found that

SUBMITTER: Li S 

PROVIDER: S-EPMC6610052 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature