Ontology highlight
ABSTRACT:
SUBMITTER: Yadav NN
PROVIDER: S-EPMC6610304 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yadav Nagendra Nath NN Lee Young-Gun YG Srivastava Nikhil N Ha Hyun-Joon HJ
Frontiers in chemistry 20190627
Alkylative ring-opening of bicyclic aziridinium ion generated from 4-hydroxybutylaziridine with organocopper reagent was achieved successfully to afford 2-alkylsubstituted piperidine in high or moderate yield. This method allowed carbon-carbon bond formation of "non-activated" aziridine via aziridinium ion ring-opening in regio- and stereo-selective manner for the first time. This newly developed reaction was applied for an efficient synthesis of alkaloid with the representative example of conin ...[more]