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Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use.


ABSTRACT: Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. This article examines the history of the development of NAC and recent developments in its use. We offer suggestions for improvements in the way NAC may be administered and outline new developments that should have major impacts on the way we manage paracetamol poisoning in the near future.

SUBMITTER: Bateman DN 

PROVIDER: S-EPMC6610312 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use.

Bateman D Nicholas DN   Dear James W JW  

Toxicology research 20190429 4


Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. This article examines the history of the development of NAC and recent developments in its use. We offer suggestions for improvements in the way NAC may be administered and outline new developments that should have major impacts on the way we manage paracetamol poisoning in the near future. ...[more]

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