Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance.
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ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC6610632 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance.
Li Weike W Turaga Ravi Chakra RC Li Xin X Sharma Malvika M Enadi Zahra Z Dunham Tompkins Sydney Nicole SN Hardy Kyle Christian KC Mishra Falguni F Tsao Jun J Liu Zhi-Ren ZR Fan Daping D Luo Ming M
Molecular therapy oncolytics 20190604
Despite reports of successful clinical cases, many tumors appear to resist infection by oncolytic viruses (OVs). To circumvent this problem, an armed vesicular stomatitis virus was constructed by inserting a transgene to express Smac/DIABLO during virus infection (VSV-S). Endogenous Smac in HeLa cells was diminished during wtVSV infection, whereas the Smac level was enhanced during VSV-S infection. Apoptosis was readily induced by VSV-S, but not wtVSV, infection. More importantly, the tumor volu ...[more]
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Project description:This SuperSeries is composed of the SubSeries listed below.
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