Ontology highlight
ABSTRACT:
SUBMITTER: Hsu J
PROVIDER: S-EPMC6610666 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Hsu Jenny J Arand Julia J Chaikovsky Andrea A Mooney Nancie A NA Demeter Janos J Brison Caileen M CM Oliverio Romane R Vogel Hannes H Rubin Seth M SM Jackson Peter K PK Sage Julien J
Nature communications 20190703 1
E2F transcription factors are central regulators of cell division and cell fate decisions. E2F4 often represents the predominant E2F activity in cells. E2F4 is a transcriptional repressor implicated in cell cycle arrest and whose repressive activity depends on its interaction with members of the RB family. Here we show that E2F4 is important for the proliferation and the survival of mouse embryonic stem cells. In these cells, E2F4 acts in part as a transcriptional activator that promotes the exp ...[more]