Ontology highlight
ABSTRACT:
SUBMITTER: Hatat B
PROVIDER: S-EPMC6611404 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Hatat Bérénice B Yahiaoui Samir S Lecoutey Cédric C Davis Audrey A Freret Thomas T Boulouard Michel M Claeysen Sylvie S Rochais Christophe C Dallemagne Patrick P
Frontiers in aging neuroscience 20190619
This work describes the conception, synthesis, <i>in vitro</i> and <i>in vivo</i> biological evaluation of novel Multi-Target Directed Ligands (MTDL) able to both activate 5-HT<sub>4</sub> receptors, block 5-HT<sub>6</sub> receptors and inhibit acetylcholinesterase activity (AChE), in order to exert a synergistic anti-amnesic effect, potentially useful in the treatment of Alzheimer's disease (AD). Indeed, both activation of 5-HT<sub>4</sub> and blockage of 5-HT<sub>6</sub> receptors led to an en ...[more]