Mitochondrial genomics of human pathogenic parasite Leishmania (Viannia) panamensis.

ABSTRACT:

Background

The human parasite Leishmania (V.) panamensis is one of the pathogenic species responsible for cutaneous leishmaniasis in Central and South America. Despite its importance in molecular parasitology, its mitochondrial genome, divided into minicircles and maxicircles, haven't been described so far.

Methods

Using NGS-based sequencing (454 and ILLUMINA), and combining de novo genome assembly and mapping strategies, we report the maxicircle kDNA annotated genome of L. (V.) panamensis, the first reference of this molecule for the subgenus Viannia. A comparative genomics approach is performed against other Leishmania and Trypanosoma species.

Results

The results show synteny of mitochondrial genes of L. (V.) panamensis</

SUBMITTER: Urrea DA 

PROVIDER: S-EPMC6611448 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature