Ontology highlight
ABSTRACT:
SUBMITTER: Fiddes IT
PROVIDER: S-EPMC6611739 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Fiddes Ian T IT Pollen Alex A AA Davis Jonathan M JM Sikela James M JM
Human genetics 20190513 7
Sequences encoding Olduvai (DUF1220) protein domains show the largest human-specific increase in copy number of any coding region in the genome and have been linked to human brain evolution. Most human-specific copies of Olduvai (119/165) are encoded by three NBPF genes that are adjacent to three human-specific NOTCH2NL genes that have been shown to promote cortical neurogenesis. Here, employing genomic, phylogenetic, and transcriptomic evidence, we show that these NOTCH2NL/NBPF gene pairs evolv ...[more]