Intrarenal Renin-Angiotensin-System Dysregulation after Kidney Transplantation.
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ABSTRACT:
SUBMITTER: Kovarik JJ
PROVIDER: S-EPMC6611786 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Intrarenal Renin-Angiotensin-System Dysregulation after Kidney Transplantation.
Kovarik Johannes J JJ Kaltenecker Christopher C CC Kopecky Chantal C Domenig Oliver O Antlanger Marlies M Werzowa Johannes J Eskandary Farsad F Kain Renate R Poglitsch Marko M Schmaldienst Sabine S Böhmig Georg A GA Säemann Marcus D MD
Scientific reports 20190705 1
Angiotensin-converting enzyme inhibitors (ACEis) are beneficial in patients with chronic kidney disease (CKD). Yet, their clinical effects after kidney transplantation (KTx) remain ambiguous and local renin-angiotensin system (RAS) regulation including the 'classical' and 'alternative' RAS has not been studied so far. Here, we investigated both systemic and kidney allograft-specific intrarenal RAS using tandem mass-spectrometry in KTx recipients with or without established ACEi therapy (n = 48). ...[more]
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