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Metagenomics and transcriptomics data from human colorectal cancer.

ABSTRACT: Colorectal cancer is a heterogenous and mostly sporadic disease, the development of which is associated with microbial dysbiosis. Recent advances in subtype classification have successfully stratified the disease using molecular profiling. To understand potential relationships between molecular mechanisms differentiating the subtypes of colorectal cancer and composition of gut microbial community, we classified a set of 34 tumour samples into molecular subtypes using RNA-sequencing gene expression profiles and determined relative abundances of bacterial taxonomic groups. To identify bacterial community composition, 16S rRNA amplicon metabarcoding was used as well as whole genome metagenomics of the non-human part of RNA-sequencing data. The generated data expands the collection of the data sources related to the disease and connects molecular aspects of the cancer with environmental impact of microbial community.

SUBMITTER: Visnovska T

PROVIDER: S-EPMC6611873 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Metagenomics and transcriptomics data from human colorectal cancer.

Visnovska Tina T Biggs Patrick J PJ Schmeier Sebastian S Frizelle Frank A FA Purcell Rachel V RV

Scientific data 20190705 1

Colorectal cancer is a heterogenous and mostly sporadic disease, the development of which is associated with microbial dysbiosis. Recent advances in subtype classification have successfully stratified the disease using molecular profiling. To understand potential relationships between molecular mechanisms differentiating the subtypes of colorectal cancer and composition of gut microbial community, we classified a set of 34 tumour samples into molecular subtypes using RNA-sequencing gene expressi ...[more]

PMID: 31278253

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