Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC6611966 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Li Guanglei G Liu Xinyi X Huang Shisheng S Zeng Yanting Y Yang Guang G Lu Zongyang Z Zhang Yu Y Ma Xu X Wang Lisheng L Huang Xingxu X Liu Jianqiao J
Molecular therapy. Nucleic acids 20190605
Base editing systems show their power in modeling and correcting the pathogenic mutations of genetic diseases. Previous studies have already demonstrated the editing efficiency of BE3-mediated C-to-T conversion in human embryos. However, the precision and efficiency of a recently developed adenine base editor (ABE), which converts A-to-G editing in human embryos, remain to be addressed. Here we selected reported pathogenic mutations to characterize the ABE in human tripronuclear embryos. We foun ...[more]