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Evidence to date: talazoparib in the treatment of breast cancer.

ABSTRACT: Approximately 5-10% of all patients diagnosed with breast cancer have germline BRCA1/2 mutations, which make their disease more susceptible to DNA-damaging agents and a new class of drugs known as poly(ADP-ribose) polymerase (PARP) inhibitors. Talazoparib is a new PARP inhibitor that has been recently approved for use in patients with metastatic breast cancer with germline BRCA mutations after a phase III trial showed superior progression-free survival when compared to standard chemotherapy. In this review, we analyze the development of talazoparib as well as its safety profile and the potential role of the combination therapy with standard cytotoxic drugs and with novel therapies.

SUBMITTER: Exman P

PROVIDER: S-EPMC6612288 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Evidence to date: talazoparib in the treatment of breast cancer.

Exman Pedro P Barroso-Sousa Romualdo R Tolaney Sara M SM

OncoTargets and therapy 20190702

Approximately 5-10% of all patients diagnosed with breast cancer have germline <i>BRCA1/2</i> mutations, which make their disease more susceptible to DNA-damaging agents and a new class of drugs known as poly(ADP-ribose) polymerase (PARP) inhibitors. Talazoparib is a new PARP inhibitor that has been recently approved for use in patients with metastatic breast cancer with germline <i>BRCA</i> mutations after a phase III trial showed superior progression-free survival when compared to standard che ...[more]

PMID: 31303769

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