Two-dose versus single-dose methotrexate for treatment of ectopic pregnancy: a meta-analysis.

ABSTRACT:

Objective

To compare the treatment success and failure rates, as well as side effects and surgery rates, between methotrexate protocols.

Data sources

PubMed, Embase, and the Cochrane library searched up to July 2018.

Study eligibility criteria

Randomized controlled trials that compared women with ectopic pregnancies receiving the single-dose, two-dose, or multi-dose methotrexate protocols.

Study appraisal and synthesis methods

Odds of treatment success, treatment failure, side effects, and surgery for tubal rupture, as well as length of follow-up until treatment success, were compared using random and fixed effects meta-analysis. Sensitivity analyses compared treatment success in the groups with high human chorionic gonadatropin (hCG) values and a large adnexal

SUBMITTER: Alur-Gupta S 

PROVIDER: S-EPMC6612469 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature