Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver.

ABSTRACT: Deciphering the impact of genetic variation on gene regulation is fundamental to understanding common, complex human diseases. Although histone modifications are important markers of gene regulatory elements of the genome, any specific histone modification has not been assayed in more than a few individuals in the human liver. As a result, the effects of genetic variation on histone modification states in the liver are poorly understood. Here, we generate the most comprehensive genome-wide dataset of two epigenetic marks, H3K4me3 and H3K27ac, and annotate thousands of putative regulatory elements in the human liver. We integrate these findings with genome-wide gene expression data collected from the same human liver tissues and high-resolution promoter-focused chromatin interaction maps co

SUBMITTER: Calıskan M 

PROVIDER: S-EPMC6612522 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature