Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Suarez S
PROVIDER: S-EPMC6612636 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Martín-Suárez Soraya S Valero Jorge J Muro-García Teresa T Encinas Juan Manuel JM
Aging cell 20190415 4
Adult neurogenesis persists in the hippocampus of most mammal species during postnatal and adult life, including humans, although it declines markedly with age. The mechanisms driving the age-dependent decline of hippocampal neurogenesis are yet not fully understood. The progressive loss of neural stem cells (NSCs) is a main factor, but the true neurogenic output depends initially on the actual number of activated NSCs in each given time point. Because the fraction of activated NSCs remains cons ...[more]