Ontology highlight
ABSTRACT:
SUBMITTER: Schafer MJ
PROVIDER: S-EPMC6612646 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Schafer Marissa J MJ Mazula Daniel L DL Brown Ashley K AK White Thomas A TA Atkinson Elizabeth E Pearsall Vesselina M VM Aversa Zaira Z Verzosa Grace C GC Smith Leslie A LA Matveyenko Aleksey A Miller Jordan D JD LeBrasseur Nathan K NK
Aging cell 20190521 4
Aging and obesity increase multimorbidity and disability risk, and determining interventions for reversing healthspan decline is a critical public health priority. Exercise and time-restricted feeding (TRF) benefit multiple health parameters when initiated in early life, but their efficacy and safety when initiated at older ages are uncertain. Here, we tested the effects of exercise versus TRF in diet-induced obese, aged mice from 20 to 24 months of age. We characterized healthspan across key do ...[more]