Ontology highlight
ABSTRACT:
SUBMITTER: Panch SR
PROVIDER: S-EPMC6612799 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Panch Sandhya R SR Srivastava Sandeep K SK Srivastava Sandeep K SK Elavia Nasha N McManus Andrew A Liu Shutong S Jin Ping P Highfill Steven L SL Li Xiaobai X Dagur Pradeep P Kochenderfer James N JN Fry Terry J TJ Mackall Crystal L CL Lee Daniel D Shah Nirali N NN Stroncek David F DF
Molecular therapy : the journal of the American Society of Gene Therapy 20190530 7
As clinical applications for chimeric antigen receptor T cell (CART) therapy extend beyond early phase trials, commercial manufacture incorporating cryopreservation steps becomes a logistical necessity. The effect of cryopreservation on CART characteristics is unclear. We retrospectively evaluated the effect of cryopreservation on product release criteria and in vivo characteristics in 158 autologous CART products from 6 single-center clinical trials. Further, from 3 healthy donor manufacturing ...[more]