Peptide-targeted liposomal delivery of dexamethasone for arthritis therapy.
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ABSTRACT:
SUBMITTER: Meka RR
PROVIDER: S-EPMC6613046 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Peptide-targeted liposomal delivery of dexamethasone for arthritis therapy.
Meka Rakeshchandra R RR Venkatesha Shivaprasad H SH Acharya Bodhraj B Moudgil Kamal D KD
Nanomedicine (London, England) 20190402 11
<b>Aim:</b> Rheumatoid arthritis is an autoimmune disease affecting the joints. Antiarthritic drugs are given systemically, thereby exposing various healthy organs to these drugs, resulting in adverse reactions. Accordingly, there is an urgent need for targeted drug delivery methods for inflamed joints. <b>Materials & methods:</b> We developed a liposomal drug delivery system using a novel peptide ligand (CKPFDRALC) named ART-2, which homes to the inflamed joints when injected intravenously to r ...[more]
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