Ontology highlight
ABSTRACT:
SUBMITTER: Lee JS
PROVIDER: S-EPMC6613284 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Lee Jong-Sun JS Mo Yan Y Gan Haiyun H Burgess Rebecca J RJ Baker Darren J DJ van Deursen Jan M JM Zhang Zhiguo Z
Proceedings of the National Academy of Sciences of the United States of America 20190617 27
Cellular senescence defines an irreversible cell growth arrest state linked to loss of tissue function and aging in mammals. This transition from proliferation to senescence is typically characterized by increased expression of the cell-cycle inhibitor p16<sup>INK4a</sup> and formation of senescence-associated heterochromatin foci (SAHF). SAHF formation depends on HIRA-mediated nucleosome assembly of histone H3.3, which is regulated by the serine/threonine protein kinase Pak2. However, it is unk ...[more]