Dataset Information

Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues: Secondary Analyses From a Randomized Clinical Trial.

ABSTRACT:

Importance

Epicardial and pericardial adipose tissues are emerging as important risk factors for cardiovascular disease, and there is a growing interest in discovering strategies to reduce the accumulation of fat in these depots.

Objective

To investigate whether a 12-week endurance or resistance training intervention regulates epicardial and pericardial adipose tissue mass.

Design, setting, and participants

Secondary analysis of a randomized, assessor-blinded clinical trial initiated on August 2016 and completed April 2018. This single-center, community-based study included 50 physically inactive participants with abdominal obesity.

Interventions

Participants were randomized to a supervised high-intensity interval endurance training (3 times a week for 45 minutes), resistance training (3 times a week for 45 minutes), or no exercise (control group).

Main outcomes and measures

Change in epicardial and pericardial adipose tissue mass assessed by magnetic resonance imaging, based on a prespecified secondary analysis plan including 3 of 5 parallel groups.

Results

Of 50 participants (mean [SD] age, 41 [14] years, 10 men [26%]; mean [SD] body mass index [calculated as weight in kilograms divided by height in meters squared], 32 [5]), 39 [78%] completed the study. Endurance training and resistance training reduced epicardial adipose tissue mass by 32% (95% CI, 10%-53%) and 24% (95% CI, 1%-46%), respectively, compared with the no exercise control group (56% [95% CI, 24%-88%]; P = .001 and 48% [95% CI, 15%-81%]; P < .001, respectively). While there was a nonsignificant reduction in pericardial adipose tissue mass after endurance training (11% [95% CI, -5% to 27%]; P = .17), resistance training significantly reduced pericardial adipose tissue mass by 31% (95% CI, 16%-47%; P < .001) when compared with the no exercise control group. Compared with the no exercise control group, there was an increase in left ventricular mass by endurance (20 g [95% CI, 11%-30%]; P < .001) and resistance training (18 g [95% CI, 8%-28%]; P < .001). Other cardiometabolic outcomes remained unchanged after the 12-week trial period.

Conclusions and relevance

In individuals with abdominal obesity, both endurance and resistance training reduced epicardial adipose tissue mass, while only resistance training reduced pericardial adipose tissue mass. These data highlight the potential preventive importance of different exercise modalities as means to reduce cardiac fat in individuals with abdominal obesity.

Trial registration

ClinicalTrials.gov identifier: NCT02901496.

SUBMITTER: Christensen RH

PROVIDER: S-EPMC6613292 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues: Secondary Analyses From a Randomized Clinical Trial.

Christensen Regitse Højgaard RH Wedell-Neergaard Anne-Sophie AS Lehrskov Louise Lang LL Legaard Grit Elster GE Dorph Emma E Larsen Monica Korsager MK Launbo Natja N Fagerlind Sabrina Ravn SR Seide Sidsel Kofoed SK Nymand Stine S Ball Maria M Vinum Nicole Buchner NB Dahl Camilla Nørfelt CN Henneberg Marie M Ried-Larsen Mathias M Boesen Mikael Ploug MP Christensen Robin R Karstoft Kristian K Krogh-Madsen Rikke R Rosenmeier Jaya Birgitte JB Pedersen Bente Klarlund BK Ellingsgaard Helga H

JAMA cardiology 20190801 8

<h4>Importance</h4>Epicardial and pericardial adipose tissues are emerging as important risk factors for cardiovascular disease, and there is a growing interest in discovering strategies to reduce the accumulation of fat in these depots.<h4>Objective</h4>To investigate whether a 12-week endurance or resistance training intervention regulates epicardial and pericardial adipose tissue mass.<h4>Design, setting, and participants</h4>Secondary analysis of a randomized, assessor-blinded clinical trial ...[more]

PMID: 31268469

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Dataset Information

Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues: Secondary Analyses From a Randomized Clinical Trial.

Importance

Objective

Design, setting, and participants

Interventions

Main outcomes and measures

Results

Conclusions and relevance

Trial registration

Publications

Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues: Secondary Analyses From a Randomized Clinical Trial.

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