Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs.
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ABSTRACT:
SUBMITTER: Roth BL
PROVIDER: S-EPMC6613815 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs.
Nature structural & molecular biology 20190703 7
Metabotropic receptors are responsible for so-called 'slow synaptic transmission' and mediate the effects of hundreds of peptide and non-peptide neurotransmitters and neuromodulators. Over the past decade or so, a revolution in membrane-protein structural determination has clarified the molecular determinants responsible for the actions of these receptors. This Review focuses on the G protein-coupled receptors (GPCRs) that are targets of neuropsychiatric drugs and shows how insights into the str ...[more]
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