Ontology highlight
ABSTRACT:
SUBMITTER: Bai J
PROVIDER: S-EPMC6613818 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Carbohydrate research 20190516
Fucosylated human milk oligosaccharides (HMOs) have important biological functions. Enzymatic synthesis of such compounds requires robust fucosyltransferases. A C-terminal 66-amino acid truncated version of Helicobacter pylori α1-3-fucosyltransferase (Hp3FT) is a good candidate. Hp3FT was biochemically characterized to identify optimal conditions for enzymatic synthesis of fucosides. While N-acetyllactosamine (LacNAc) and lactose were both suitable acceptors, the former is preferred. At a low gu ...[more]