Ontology highlight
ABSTRACT:
SUBMITTER: Martinez FD
PROVIDER: S-EPMC6613822 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Immunology and allergy clinics of North America 20190501 2
Inappropriate responses to respiratory viruses, especially rhinovirus, and early allergic sensitization are the strongest contributors to the inception and persistence of early onset asthma. The ORMDL3 asthma locus in chromosome 17q seems to exert its effects by increasing susceptibility to human rhinovirus in early life. Being raised on animal farms is highly protective against the development of asthma, and this protective effect is mediated by exposure to microbes. Two trials in high-risk you ...[more]